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Target intelligence / Profile preview
Alloimmune Defense Receptor (None)
- Target
- None
- Molecular classification
- Synthetic Receptor, Chimeric Receptor
01
Overview
The Alloimmune Defense Receptor (ADR) is a synthetic, engineered receptor designed to enhance the persistence and efficacy of allogeneic cell therapies by selectively targeting and eliminating activated host immune cells that would otherwise attack and reject the therapeutic cells. ADR-expressing therapeutic cells recognize and bind to 4-1BB on activated host T and NK cells, leading to the deletion of these alloreactive lymphocytes.
02
Mechanism of action
Selective depletion of alloreactive/activated recipient lymphocytes
03
Biological functions
Immune response modulationT cell depletionNK cell depletionProtection of allogeneic cells
04
Disease associations
Hematologic MalignanciesSolid Tumors
05
Safety considerations
Potential for off-target effectsImmunogenicity of the synthetic receptorCytokine release syndromeOn-target, off-tumor toxicity
06
Biomarkers
4-1BB expression on activated T and NK cells
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