ALMS1 pseudogene 1 (ALMS1P1)

ALMS1 pseudogene 1 (ALMS1P1) is a genomic sequence derived from the ALMS1 gene, but unlike ALMS1, it does not encode a functional protein. Pseudogenes generally arise from gene duplication or retrotransposition events and are often transcriptionally silent, although some may produce non-coding RNAs. ALMS1P1 shares sequence similarity with the active ALMS1 gene, whose protein product is localized to centrosomes and basal bodies and plays roles in ciliary function, intracellular trafficking, and metabolic regulation[7]. Mutations in the functional ALMS1 gene—not the pseudogene—result in Alström syndrome, a complex disorder characterized by obesity, diabetes, neurosensory deficits, and multi-organ involvement[1][2][4]. There is no evidence that ALMS1P1 acts as a drug target, biomarker, or has direct biological or pathological function. Key points: - ALMS1P1 is a pseudogene, not a protein-coding gene[7]. - The clinically relevant target is ALMS1, not ALMS1P1. - The entry is incorrect if interpreted as a molecular target for therapeutic intervention. If you are seeking information on the functional gene and protein, please refer to ALMS1 (centrosome and basal body associated protein), which is linked to Alström syndrome and participates in centrosome, ciliary, and metabolic processes[1][2][4].

Other names

ALMS1LALMS1Pcentrosome and basal body associated protein pseudogene 1Alstrom syndrome 1 pseudogene