Target intelligence / Profile preview

Aln g 1

Target: Aln g 1
Molecular classification: PR-10 protein, Allergen

Overview

Aln g 1 is the major allergen found in alder pollen (Alnus species) and belongs to the PR-10 protein family. It binds hydrophobic ligands and contains IgE-binding sites, which contribute to cross-reactivity with other tree pollens like birch and hazel. Aln g 1 acts as a sensitizer, triggering type I hypersensitivity reactions and upregulating alarmins in epithelial cells, leading to allergic rhinitis, conjunctivitis, and asthma symptoms during the pollination season.

Other names: Alder pollen allergenGrey alder allergen 1

Biological functions

Binds hydrophobic ligandsTriggers IgE-mediated allergic reactionsUpregulation of alarmins in epithelial cells

Disease associations

Allergic rhinitisConjunctivitisAsthmaOral Allergy Syndrome

Safety considerations

Cross-reactivity with other tree pollens (Birch, Hazel, Oak, Beech, Hornbeam)

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