Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C (MGAT4C)

Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C (MGAT4C) is a member of the MGAT4 family of glycosyltransferases, predicted to catalyze the introduction of a β1-4-linked N-acetylglucosamine (GlcNAc) branch onto the α1-3 mannose arm of N-linked glycans during protein N-glycosylation[1][3]. It is classified within the GT54 glycosyltransferase family and is encoded by the MGAT4C gene on chromosome 12q21.3. Although orthologs in other species (such as fish and chicken) have demonstrable enzyme activity (GnT-VI)[2], enzymatic activity of human MGAT4C has not been confirmed[1][2]. The protein is predominantly expressed in adult brain, and its specific biological or physiological roles in humans remain unclear[1][2]. MGAT4C is genetically associated with disorders such as congenital muscular dystrophy-dystroglycanopathy type A11 and autism spectrum disorder, though the molecular mechanism is uncharacterized[3]. Currently, there are no approved drugs targeting MGAT4C, nor established mechanisms of pharmacological modulation. MGAT4C remains primarily a gene of predicted function with unresolved physiological significance in the human glycosylation pathway[1][2][3].

Other names

MGAT4CGnT-IVcGnT-VIhGnT-IV-HGlcNAc-T IVcN-acetylglucosaminyltransferase IVcHGNT-IV-HN-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVcUDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVcGNTIVH