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Target intelligence / Profile preview
Alpha-1-microglobulin (A1M)
- Target
- A1M
- Molecular classification
- Lipocalin superfamily, Glycoprotein
01
Overview
Alpha‑1‑microglobulin is a multifunctional glycoprotein involved primarily in protection against oxidative stress through heme binding/degradation and radical scavenging activities. Its presence—and especially its elevation—in urine serves as an important biomarker for proximal tubule dysfunction and related renal pathologies. Ongoing research explores its broader diagnostic value and therapeutic potential across several disease states.
- Other names
- α1-microglobulinProtein HC
02
Biological functions
Heme bindingHeme degradationRadical scavengingReductase activityTissue protectionImmunomodulationInhibition of renal stone formation
03
Disease associations
Tubular kidney dysfunctionNephropathyPreeclampsiaHIV infectionMood disordersOxidative stress related diseases
04
Biomarkers
Urinary A1M (marker for tubular kidney dysfunction)Serum/plasma A1M (marker for liver/kidney function)
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