Gosset Molecular Classification
G protein-coupled receptor, Receptor
Other Names
α₁Α-adrenoceptor, alpha-1C adrenergic receptor (obsolete)
Disease Roles
Alpha-1A adrenergic receptor Overview
The Alpha-1A adrenergic receptor (ADRA1A) is a G protein-coupled receptor activated by catecholamines such as norepinephrine and epinephrine. Primarily coupled to Gq/11, it stimulates phospholipase C, increasing intracellular calcium and influencing smooth muscle contraction, synaptic transmission, and cell proliferation. It is a target for hypertension and BPH treatments.
Mechanism of Action
Agonists stimulate, antagonists block the receptor leading to downstream effects on smooth muscle contraction and neuronal activity.
Biological Functions
Smooth muscle contraction
Modulation of synaptic transmission
Cell growth/proliferation
Neurogenesis
Gliogenesis
Signal transduction
Disease Associations
Hypertension
Benign prostatic hyperplasia
Schizophrenia (weight gain association)
Safety Considerations
No safety concerns listed
Interacting Drugs
Cirazoline hydrochloride