Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Alpha-1B adrenergic receptor (ADRA1B)
- Target
- ADRA1B
- Molecular classification
- G protein-coupled receptor, GPCR, Adrenergic receptor
01
Overview
The alpha-1B adrenergic receptor (ADRA1B) is a G protein-coupled receptor that mediates physiological responses to norepinephrine and epinephrine. It plays a role in vasoconstriction, cell proliferation, and metabolic modulation. Dysregulation may contribute to oncogenesis. It is a therapeutic target for schizophrenia, PTSD, benign prostatic hyperplasia, and other genitourinary disorders.
- Other names
- alpha1B-adrenoreceptorADRA1B receptor
02
Mechanism of action
Activation of Gq/11 proteins leading to stimulation of phospholipase C and increased intracellular calcium.
03
Biological functions
Regulation of vasoconstrictionModulation of neuron-glial signalingCell proliferationMitogenic responsesHepatic glucose metabolismSkeletal muscle fatty acid oxidationSignal transduction
04
Disease associations
Oncogenic transformation (potential)Schizophrenia (potential)PTSD (potential)Benign prostatic hyperplasia (potential)Genitourinary disorders (potential)
05
Safety considerations
Potential for oncogenic transformation when overexpressed or dysregulated in certain cells.Cardiovascular side effects due to vasoconstriction regulation
06
Interacting drugs
Norepinephrine
2 more in the full profile.
Beyond the preview
Go deeper on Alpha-1B adrenergic receptor (ADRA1B).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Alpha-1B adrenergic receptor (ADRA1B).