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Alpha-1D Adrenergic Receptor (None)
- Target
- None
- Molecular classification
- G protein-coupled receptor, GPCR
01
Overview
The alpha-1D adrenergic receptor (α1D adrenoreceptor), encoded by the ADRA1D gene, is a G protein-coupled receptor primarily expressed in vascular smooth muscle, especially epicardial coronary arteries. It mediates vasoconstriction and regulates systemic blood pressure. Selective antagonism of α1D may offer coronary vasodilation without negative cardiac side effects.
- Other names
- α1D adrenoreceptorADRA1D
02
Mechanism of action
Activation by catecholamines leads to Gq/11 protein activation, resulting in increased intracellular calcium influx and smooth muscle contraction, particularly in vascular tissues. Antagonists block this receptor, inhibiting vasoconstriction.
03
Biological functions
VasoconstrictionSmooth muscle contractionRegulation of systemic blood pressureSignal transductionRegulation of cell growth and proliferation
04
Disease associations
HypertensionHeart failureGlaucomaProstate hyperplasiaSexual dysfunctionSolid tumors/cancer
05
Safety considerations
Non-selective alpha-adrenergic antagonists can have negative cardiac side effects.Off-target effects due to lack of subtype selectivity can lead to unintended consequences.
06
Interacting drugs
Norepinephrine
6 more in the full profile.
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