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Target intelligence / Profile preview
Alpha-2 antiplasmin (α2AP)
- Target
- α2AP
- Molecular classification
- Serine protease inhibitors (serpins)
01
Overview
Alpha-2 antiplasmin (α2AP), also known as plasmin inhibitor, is a key serine protease inhibitor (serpin) that plays a central role in regulating fibrinolysis by inactivating plasmin, the primary enzyme responsible for breaking down blood clots. It is primarily synthesized by hepatocytes in the liver and released into circulation.
- Other names
- α2-antiplasminα2-plasmin inhibitorPlasmin inhibitorSERPINF2
02
Mechanism of action
Inhibits plasmin by forming a stable complex, preventing fibrin clot breakdown.
03
Biological functions
Inhibition of fibrinolysisRegulation of hemostasisPlasmin neutralization
04
Disease associations
Bleeding disorders (deficiency)Thrombosis (elevated levels)Ischemic stroke (elevated levels)
05
Safety considerations
Deficiency leads to increased risk of bleedingElevated levels associated with increased risk of ischemic stroke
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