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Target intelligence / Profile preview
Alpha 2-Plasmin Inhibitor (α2-PI)
- Target
- α2-PI
- Molecular classification
- Serine Protease Inhibitor, Serpin
01
Overview
Alpha 2-plasmin inhibitor (α2-antiplasmin, α2-PI, plasmin inhibitor, or SERPINF2) is a critical serine protease inhibitor (serpin) that plays a fundamental role in regulating fibrinolysis and maintaining hemostatic balance. It serves as the primary, fast-acting inhibitor of plasmin, accounting for approximately 90% of plasmin inhibition in vivo. It inactivates plasmin through several mechanisms and contributes to clot stability. It has emerged as a potential therapeutic target for various thrombotic and vascular disorders.
- Other names
- α2-antiplasminPlasmin InhibitorSERPINF2
02
Mechanism of action
Inhibits plasmin activity by forming covalent complexes and preventing plasminogen-fibrin binding.
03
Biological functions
Inhibition of PlasminRegulation of FibrinolysisClot StabilizationInhibition of vascular remodeling
04
Disease associations
Bleeding DisordersLiver DiseaseCardiovascular DiseaseCerebrovascular DiseaseThrombotic Disorders
05
Safety considerations
Potential for increased risk of thrombosis with elevated levelsBleeding risk with deficiency
06
Biomarkers
Alpha 2-antiplasmin levels for bleeding risk assessmentAlpha 2-antiplasmin levels for cardiovascular risk assessment
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