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Target intelligence / Profile preview
Adrenergic Alpha–2C Receptor (ADRA2C)
- Target
- ADRA2C
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
The adrenergic alpha–2C receptor (ADRA2C) is a G protein-coupled receptor involved in regulating neurotransmitter release from sympathetic nerves and central nervous system adrenergic neurons. It modulates smooth muscle contraction, vasoconstriction, and insulin secretion. Agonists targeting this receptor are used clinically for their sedative, analgesic, and muscle relaxant properties. Dysregulation may be implicated in cardiovascular diseases or neuropsychiatric disorders.
- Other names
- ADRA2L2ADRA2RL2Alpha-2 adrenergic receptor subtype C4Alpha-2C adrenoceptorAlpha-2CAR
02
Mechanism of action
Catecholamine-induced inhibition of adenylate cyclase via G proteins, resulting in decreased cAMP levels.
03
Biological functions
Regulation of neurotransmitter releaseNegative feedback inhibition on norepinephrine releaseModulation of smooth muscle contractionVasoconstrictionNegative regulation of insulin secretionPositive regulation of MAPK cascade signaling
04
Disease associations
Cardiovascular diseasesNeuropsychiatric disorders
05
Safety considerations
Sedative propertiesAnalgesic propertiesMuscle relaxant propertiesPotential implications in cardiovascular diseases or neuropsychiatric disorders
06
Interacting drugs
(R)-3-Nitrobiphenyline
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