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Target intelligence / Profile preview
Alpha-7 Nicotinic Acetylcholine Receptor (α7 nAChR)
- Target
- α7 nAChR
- Molecular classification
- Ligand-gated ion channel, Cys-loop receptor superfamily, Receptor
01
Overview
The alpha-7 nicotinic acetylcholine receptor (α7 nAChR) is a homopentameric ligand-gated ion channel highly permeable to calcium ions. It plays crucial roles in neurotransmission, synaptic plasticity, and inflammation through the cholinergic anti-inflammatory pathway. α7 nAChR activation leads to calcium influx and downstream signaling cascades, impacting neuronal function, immune responses, and cell survival. It is implicated in various diseases, including cognitive disorders, schizophrenia, and cancer, making it a therapeutic target for several investigational drugs.
- Other names
- α7 nicotinic receptorCHRNA7
02
Mechanism of action
Agonists bind to the α7 nAChR, causing a conformational change that opens the ion channel, allowing for calcium influx and subsequent downstream signaling. Antagonists block agonist binding, preventing channel opening and calcium influx. Positive allosteric modulators enhance the effects of agonists.
03
Biological functions
Fast synaptic transmissionNeurotransmitter releaseAction potential generationSynaptic plasticityCalcium influxInflammation regulationAnti-apoptotic signalingAutophagy induction
04
Disease associations
Cognitive impairmentNeurodegenerative diseaseSchizophreniaInflammationAtherosclerosisCancer
05
Interacting drugs
Acetylcholine
12 more in the full profile.
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