Alpha-actinin-1 (ACTN1)

Alpha-actinin-1 (ACTN1) is a non-muscle cytoskeletal protein belonging to the spectrin superfamily, primarily functioning as a **F-actin cross-linking protein** that anchors actin filaments to various intracellular structures[1][2][3][4]. Expressed in non-muscle cells, ACTN1 is localized along microfilament bundles and adherens-type junctions, where it tethers actin to the plasma membrane and stabilizes cell–cell adhesion. It plays central roles in **cytoskeletal organization, cell adhesion, migration, and signal transduction**. In immune cells such as T lymphocytes, it mediates cytoskeletal interactions for immune synapse formation. Disease associations include bleeding disorders (notably macrothrombocytopenia)[3], and tumor-specific splicing of ACTN1 has been observed in certain cancers, suggesting biomarker utility[1]. No drugs directly target ACTN1, but its interactome includes receptors, actin-binding partners, and signaling molecules[2][3][4].

Other names

Alpha-actinin-1ACTN1Alpha-actinin cytoskeletal isoformF-actin cross-linking proteinNon-muscle alpha-actinin-1BDPLT15actinin 1 smooth muscleepididymis secretory sperm binding proteinnon-muscle alpha-actinin-1

Not applicable (no specific drugs targeting ACTN1 directly)