Alpha-amylase 1C (AMY1C)

Alpha-amylase 1C (AMY1C) is a calcium-binding secreted enzyme predominantly produced by the salivary glands in humans, responsible for catalyzing the hydrolysis of internal (1→4)-alpha-D-glucosidic bonds in oligosaccharides and polysaccharides, particularly starch and glycogen, leading to their breakdown into smaller sugars like maltose and glucose during the initial step of digestion in the oral cavity[1][5][7]. The AMY1 gene family exhibits copy number variation, impacting enzyme production and possible clinical associations, including metabolic traits[8]. This gene is closely related to other amylase isoenzymes found in the pancreas and has been implicated in certain diseases such as Autism Spectrum Disorder[1][8].

Other names

Alpha-amylase 1CAMY1CAMY11,4-alpha-D-glucan glucanohydrolase 1alpha-amylase 1alpha-amylase 1Aamylase alpha 1C (salivary)amylase, salivaryalpha-1Cglycogenasesalivary alpha-amylasesalivary amylase alpha 1C