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Target intelligence / Profile preview
Alpha-beta T cell receptor (αβTCR)
- Target
- αβTCR
- Molecular classification
- Receptor, Immunoglobulin superfamily
01
Overview
The alpha-beta T cell receptor (αβ TCR) is a heterodimeric receptor expressed on the surface of most T lymphocytes. It recognizes peptide antigens presented by MHC molecules, initiating T cell activation and adaptive immune responses. The αβ TCR consists of alpha and beta chains, each with variable and constant regions. The variable regions mediate antigen recognition, while the constant regions associate with CD3 signaling complexes to trigger intracellular signaling cascades. αβ TCR diversity arises from V(D)J recombination during T cell development.
- Other names
- T cell receptor alpha/betaTCR αβ
02
Mechanism of action
Modulation of T cell activation
03
Biological functions
Antigen recognitionT cell activationImmune responseSignal transduction
04
Disease associations
AutoimmunityInfectionCancerImmunodeficiency
05
Safety considerations
Cytokine release syndromeOff-target effectsImmune-related adverse events
06
Biomarkers
TCR clonalityTCR sequence diversityTCR expression level
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