Target intelligence / Profile preview

Alpha C N-terminal domain (AlpCN)

Target: AlpCN
Molecular classification: Surface protein, Antigen, Alpha-like protein family

Overview

The Alpha C N-terminal domain (AlpCN) is a surface-exposed, immunogenic portion of the Alpha C protein, a member of the Alpha-like protein family found in Group B Streptococcus (GBS). AlpCN is a key vaccine target due to its broad prevalence across GBS strains and its ability to elicit protective antibody responses. It plays a role in bacterial adhesion and immune evasion.

Other names: Alpha-like protein C N-terminal domainAlpC N-terminal domain

Mechanism of action

Antibody-mediated neutralization of bacterial adhesion and/or promotion of opsonophagocytosis

Biological functions

Adhesion to host cellsImmune evasionSerosubtype markerBacterial virulence

Disease associations

InfectionGroup B Streptococcus infectionNeonatal infection

Safety considerations

Potential for off-target effects due to sequence similarity with other proteinsRisk of inducing autoimmune responses (though preclinical data suggests this is low for AlpCN-based vaccines)

Biomarkers

Antibody levels against AlpCNAlpCN serotype

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