Drug pipeline
Explore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Alpha-dystroglycan
- Molecular classification
- Peripheral membrane glycoprotein, Extracellular matrix receptor, Cell adhesion molecule
01
Overview
Alpha-dystroglycan (α-DG) is an extracellular peripheral membrane glycoprotein that acts as a crucial link between the extracellular matrix (ECM) and the cytoskeleton. Synthesized from the DAG1 gene, it is heavily glycosylated, a modification essential for binding ECM proteins like laminins. This interaction provides structural support to muscle fibers and facilitates cell signaling. Aberrant glycosylation leads to α-dystroglycanopathies, a spectrum of congenital muscular dystrophies. Furthermore, α-DG serves as a receptor for several viruses, including Lassa fever virus. Its widespread expression underscores its importance in cell adhesion and tissue integrity across various organ systems.
02
Mechanism of action
N/A
03
Biological functions
Extracellular matrix organizationCell adhesionCytoskeletal anchoringSignal transductionViral entry receptor
04
Disease associations
Muscular dystrophyAlpha-dystroglycanopathiesViral infection
05
Safety considerations
Off-target effects due to widespread tissue distributionPotential for immune response to modified alpha-dystroglycanChallenges in achieving specific glycosylation patterns for therapeutic efficacy
06
Biomarkers
Glycosylation status of alpha-dystroglycanExpression levels of alpha-dystroglycan
Beyond the preview
Go deeper on Alpha-dystroglycan.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Follow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Compare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Investigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Explore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Connect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Alpha-dystroglycan.