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Target intelligence / Profile preview
Alpha-fetoprotein Receptor (AFPR)
- Target
- AFPR
- Molecular classification
- Receptor, Mucin Receptor Family, Scavenger Receptor Family
01
Overview
Alpha-fetoprotein receptor (AFPR) is a cell surface receptor that mediates the binding and internalization of alpha-fetoprotein (AFP). It is expressed on various cell types, particularly cancer cells and myeloid-derived suppressor cells, and plays a crucial role in cancer progression by mediating AFP's effects on cell proliferation, migration, and immune escape. AFPRs are potential therapeutic targets for cancer treatment, including targeted drug delivery and CAR T-cell therapy.
- Other names
- AFP Receptor
02
Mechanism of action
Targeted drug delivery to cancer cells expressing AFPR
03
Biological functions
EndocytosisSignal transductionCell proliferationCell migrationImmune modulationNutrient transport
04
Disease associations
CancerHepatocellular carcinoma (HCC)
05
Safety considerations
Potential off-target effects due to AFPR expression in fetal cells
06
Interacting drugs
AFP-maytansine conjugates
1 more in the full profile.
07
Biomarkers
AFPR expression level in cancer cells
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