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Target intelligence / Profile preview
Alpha-glucosidase II (GII)
- Target
- GII
- Molecular classification
- Enzyme, Glycosyl hydrolase 31 family
01
Overview
Alpha-glucosidase II (GII) is a heterodimeric enzyme located in the endoplasmic reticulum (ER) that plays a critical role in glycoprotein processing and maturation. It catalyzes the removal of two α1-3-linked glucose residues from N-linked oligosaccharides, which is essential for proper protein folding, stability, and trafficking. GII consists of a catalytic alpha subunit (GIIα) and a regulatory beta subunit (GIIβ). Inhibition of GII is being explored as a therapeutic strategy for various diseases, including viral infections, cancer, and diabetes.
02
Mechanism of action
Inhibition of alpha-glucosidase II disrupts N-glycan processing, affecting glycoprotein folding and function.
03
Biological functions
Glycoprotein foldingProtein quality controlN-glycan processing
04
Disease associations
CancerViral infectionDiabetesNeurodegenerative diseasesMental retardation
05
Safety considerations
Potential for off-target effects due to broad tissue expression.
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