Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Alpha-glucosidase II (GII)
- Target
- GII
- Molecular classification
- Enzyme, Glycosyl hydrolase 31 family
01
Overview
Alpha-glucosidase II (GII) is a heterodimeric enzyme located in the endoplasmic reticulum (ER) that plays a critical role in glycoprotein processing and maturation. It catalyzes the removal of two α1-3-linked glucose residues from N-linked oligosaccharides, which is essential for proper protein folding, stability, and trafficking. GII consists of a catalytic alpha subunit (GIIα) and a regulatory beta subunit (GIIβ). Inhibition of GII is being explored as a therapeutic strategy for various diseases, including viral infections, cancer, and diabetes.
02
Mechanism of action
Inhibition of alpha-glucosidase II disrupts N-glycan processing, affecting glycoprotein folding and function.
03
Biological functions
Glycoprotein foldingProtein quality controlN-glycan processing
04
Disease associations
CancerViral infectionDiabetesNeurodegenerative diseasesMental retardation
05
Safety considerations
Potential for off-target effects due to broad tissue expression.
Beyond the preview
Go deeper on Alpha-glucosidase II (GII).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Alpha-glucosidase II (GII).