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Target intelligence / Profile preview
Alpha-Ketoglutarate Dehydrogenase Complex (α-KGDH)
- Target
- α-KGDH
- Molecular classification
- Enzyme, Oxidoreductase, Dehydrogenase complex
01
Overview
Alpha-ketoglutarate dehydrogenase complex (α-KGDH or KGDHC) is a large mitochondrial enzyme complex that catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA and CO₂ in the citric acid (Krebs) cycle. This reaction also produces NADH, which directly supplies electrons to the respiratory chain for ATP production. Impaired function of this enzyme has been found to be characteristic for several neurodegenerative diseases.
- Other names
- KGDHC2-oxoglutarate dehydrogenase complexα-ketoglutarate dehydrogenase
02
Mechanism of action
N/A
03
Biological functions
Citric acid cycleOxidative decarboxylationATP productionRedox homeostasisCellular respiration
04
Disease associations
Neurodegenerative diseaseAlzheimer's diseaseMetabolic encephalopathyAlpha-ketoglutarate dehydrogenase deficiency syndrome
05
Safety considerations
Impaired energy metabolismReactive oxygen species (ROS) productionNeurological dysfunction
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