Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 (ALKBH3)

Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 (ALKBH3) is a Fe(II)- and 2-oxoglutarate-dependent enzyme that demethylates specific alkylated bases in single-stranded DNA and RNA, particularly 1-methyladenosine (m^1A) and 3-methylcytidine (m^3C)[2][3][4]. In DNA, ALKBH3 repairs lesions caused by alkylating agents and helps maintain genomic integrity. In RNA, especially tRNA, it modulates modifications that affect translation efficiency, ribosome assembly, and tumor cell survival. ALKBH3 is highly expressed in several cancers, promoting cell proliferation, migration, invasion, and resistance to apoptosis. Its essential roles in nucleic acid repair and RNA biology, along with its frequent overexpression in tumors, make it a compelling therapeutic target in oncology[3][4][7].

Other names

ABH3DEPC1hABH3DEPC-1Alkylated DNA repair protein alkB homolog 3Prostate cancer antigen 1PCA1

Inhibition leads to accumulation of methylated DNA/RNA bases, causing DNA damage, reduced tRNA function, impaired translation, cell cycle arrest, apoptosis, and tumor suppression[4][5].