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Fat mass and obesity-associated protein (FTO)
- Target
- FTO
- Molecular classification
- Enzyme, Dioxygenase, Non-heme iron(II)/alpha-KG dependent dioxygenase
01
Overview
FTO is an alpha-ketoglutarate-dependent dioxygenase that catalyzes the oxidative demethylation of nucleic acids, particularly N6-methyladenosine (m6A) in RNA. It plays a critical role in energy homeostasis, adipogenesis, thermogenesis, and regulation of body mass index, and is a major genetic determinant of obesity risk. FTO is also implicated in metabolic diseases and some cancers, making it a therapeutic target.
- Other names
- Alpha-ketoglutarate-dependent dioxygenase FTO
02
Mechanism of action
Inhibition of FTO enzymatic activity (oxidative demethylation of m6A)
03
Biological functions
Demethylation of nucleic acidsRegulation of energy balanceAdipogenesisThermogenesisRegulation of body mass index
04
Disease associations
ObesityType 2 diabetesCancerMetabolic disease
05
Safety considerations
Potential off-target effects of FTO inhibitorsAltered neural responses to food cuesComplex regulation of FTO expression and activity
06
Interacting drugs
FB23
5 more in the full profile.
07
Biomarkers
rs9939609 (SNP)m6A levels in RNA
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