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Alpha-Klotho (α-Klotho)
- Target
- α-Klotho
- Molecular classification
- Single-pass transmembrane protein, Co-receptor, Hormone (soluble form)
01
Overview
Alpha-Klotho (α-Klotho) is a transmembrane protein with a secreted soluble form, playing crucial roles in mineral metabolism, aging, and cellular protection. As a co-receptor for FGF23, it regulates phosphate and vitamin D metabolism in the kidneys. Its deficiency is linked to premature aging and kidney disease, making it a potential therapeutic target.
- Other names
- KlothoKL
02
Mechanism of action
Acts as a co-receptor for FGF23, modulating downstream signaling pathways involved in phosphate regulation, vitamin D metabolism, and other cellular processes. Soluble form interacts with FGFRs and TGF-beta receptors.
03
Biological functions
FGF23 co-receptor activityMineral homeostasis (calcium and phosphate regulation)Aging suppressionCellular protection against oxidative stressInhibition of apoptosisPromotion of angiogenesisWnt signaling modulationMetabolic regulationRegulation of inflammationReduction of fibrosisEnhancement of autophagyImprovement of insulin sensitivityAntioxidant effects
04
Disease associations
Premature aging syndromesDisturbed calcium/phosphate homeostasisChronic kidney diseaseMetabolic bone disorders
05
Safety considerations
Potential for off-target effects due to broad interaction with FGFRs and TGF-beta receptorsComplex pleiotropic effects requiring careful consideration in therapeutic applications
06
Biomarkers
Soluble α-Klotho levels in blood/urine
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