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Target intelligence / Profile preview
Alpha-lactalbumin-expressing tumor cells
- Molecular classification
- Protein
01
Overview
Alpha-lactalbumin is a protein found in human milk that plays a role in lactose synthesis. It can form a complex with oleic acid, known as HAMLET, which has been shown to induce apoptosis in tumor cells while sparing healthy cells. The term "Alpha-lactalbumin-expressing tumor cells" refers to cells that express this protein, but it is not a specific therapeutic target itself. Instead, the HAMLET complex derived from alpha-lactalbumin is of therapeutic interest for its potential to target cancer cells[1][4][6].
- Other names
- Alpha-lactalbuminHAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells)
02
Mechanism of action
Induction of apoptosis in tumor cells through the HAMLET complex.
03
Biological functions
Apoptosis (through HAMLET complex)Lactose synthesis regulationPotential role in cancer prevention
04
Disease associations
Cancer (HAMLET complex has tumoricidal properties)
05
Safety considerations
The therapeutic use of HAMLET or related compounds is still under investigation, and safety concerns would depend on specific applications.
06
Interacting drugs
HAMLET
1 more in the full profile.
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