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Alpha-linolenic Acid Receptor
- Molecular classification
- Nuclear Receptor, Transcription factor
01
Overview
There is no single, well-defined "alpha-linolenic acid receptor." The term refers collectively to the molecular targets, including nuclear hormone receptors like PPARs and LXRs, that mediate the diverse physiological actions of alpha-linolenic acid through gene regulation and cell signaling mechanisms.
- Other names
- ALA ReceptorPPARs (Peroxisome proliferator-activated receptors)LXRs (Liver X receptors)
02
Mechanism of action
Alpha-linolenic acid and its metabolites modulate gene expression by binding to nuclear hormone receptors such as PPARs and LXRs, altering cell membrane fluidity, influencing signal transduction pathways related to inflammation, and being metabolized into bioactive oxylipins via lipoxygenase (LOX), cyclooxygenase (COX), and cytochrome P450 pathways.
03
Biological functions
Lipid metabolism regulationAnti-inflammatory signalingGene expression modulationMembrane fluiditySignal transductionImmunomodulation
04
Disease associations
Cardiovascular diseaseNeurodegenerative diseaseInflammation
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