Target intelligence / Profile preview

Alpha-mannosidase

Molecular classification: Enzyme, Exoglycosidase

Overview

Alpha-mannosidase is an enzyme that catalyzes the cleavage of the α form of mannose from glycoproteins and oligosaccharides. It plays a critical role in the degradation of N-linked oligosaccharides during glycoprotein catabolism, specifically by cleaving α-1,2, α-1,3, and α-1,6 mannosidic linkages. Deficiency or dysfunction leads to alpha-mannosidosis, a rare autosomal recessive lysosomal storage disorder.

Biological functions

Glycoprotein catabolismDegradation of N-linked glycansMannose trimmingProtein folding

Disease associations

Alpha-MannosidosisLysosomal storage disorder

Safety considerations

Progressive cellular damageIntellectual disabilityMotor function abnormalitiesHearing lossImmunodeficiency

Biomarkers

Deficient enzyme activity (for diagnosis and treatment monitoring)

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