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Target intelligence / Profile preview
Alpha-mannosidase 1 (AMan1)
- Target
- AMan1
- Molecular classification
- Enzyme, Glycoside hydrolase family 47, Class I alpha-1,2-mannosidase
01
Overview
Alpha-mannosidase 1 is a crucial enzyme involved in glycoprotein processing and N-glycan modification. This enzyme specifically catalyzes the cleavage of alpha-mannose residues from oligosaccharides, playing a vital role in protein quality control and glycoprotein maturation. Deficiencies or dysfunctions in alpha-mannosidase enzymes can lead to various pathological conditions such as alpha-mannosidosis.
- Other names
- α-mannosidase 1Alpha-1,2-mannosidaseα-D-mannoside mannohydrolaseAtMANIaAtMANIb
02
Mechanism of action
Inhibition of alpha-mannosidase activity, preventing the cleavage of alpha-mannose residues from oligosaccharides
03
Biological functions
N-Glycan processingProtein quality controlGlycoprotein maturationImmune system regulation
04
Disease associations
Alpha-mannosidosisMannosidosisImmune system-related diseasesNeurodegenerative disordersCancers
05
Safety considerations
Potential for off-target effects due to the presence of multiple alpha-mannosidase isoformsDisruption of N-glycan processing can have broad impacts on cellular function
06
Interacting drugs
1-deoxymannojirimycin
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