Alpha-mannosidase 2x (MAN2A2)

Alpha-mannosidase 2x (MAN2A2) is a Golgi-resident glycosidase enzyme that catalyzes the committed step in the maturation of complex N-glycans, converting high-mannose structures to complex N-glycans by hydrolyzing specific mannose residues[1][2][6]. This activity is essential for proper protein folding, trafficking, and—specifically in the testis—for cell–cell adhesion processes critical for spermatogenesis. Genetic disruption of MAN2A2 alters glycan structures, causing defects in protein processing and cellular adhesion, and is associated with several reproductive and developmental diseases such as various forms of spermatogenic failure, Hirschsprung disease, and congenital bilateral absence of the vas deferens[1][2]. The enzyme is predicted to be membrane-bound and localized to the Golgi apparatus[2][3][6]. While MAN2A2 is considered an enzyme of therapeutic interest based on gene-function and disease-association studies, no small-molecule inhibitors or drugs are currently known to target it directly[2][6].

Other names

MANA2Xalpha-MIIxMannosidase alpha class 2A member 2Man IIxAlpha-mannosidase IIxMannosyl-oligosaccharide 1,3-1,6-alpha-mannosidasemanosidase, alpha-, type II, isozyme X