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Alpha-mannosidase I (MAN1)
- Target
- MAN1
- Molecular classification
- Enzyme, Glycoside Hydrolase
01
Overview
Alpha-mannosidase I is an enzyme that plays a crucial role in the maturation and processing of N-linked glycans during glycoprotein biosynthesis. It catalyzes the hydrolysis of specific mannose residues from oligosaccharides, converting Man9GlcNAc2 to Man5GlcNAc2, which is essential for generating complex N-glycan structures on proteins. Mannosidase I also functions in protein folding quality control and has been shown to modulate immune cell function, specifically inhibiting naive CD4+ T cell activation. Deficiency or inhibition of mannosidases can lead to disorders such as mannosidosis.
- Other names
- α-mannosidase IMannosidase IAMAN1A1MAN1B1AtMANIa (Arabidopsis thaliana)AtMANIb (Arabidopsis thaliana)
02
Mechanism of action
Inhibition of alpha-mannosidase I, preventing the trimming of mannose residues from N-glycans.
03
Biological functions
Glycoprotein biosynthesisN-glycan processingProtein folding quality controlImmune modulation
04
Disease associations
Lysosomal storage diseaseMannosidosis
05
Safety considerations
Potential for disrupting glycoprotein biosynthesisOff-target effects on other glycosidases
06
Interacting drugs
Kifunensine
1 more in the full profile.
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