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Target intelligence / Profile preview
Alpha platelet-derived growth factor receptor (PDGFRA)
- Target
- PDGFRA
- Molecular classification
- Receptor tyrosine kinase
01
Overview
The alpha platelet-derived growth factor receptor (PDGFRA), also known as CD140a, is a cell surface receptor tyrosine kinase that binds PDGF isoforms, activating signaling pathways regulating cell growth, differentiation, and development. It plays critical roles in embryonic development and tissue maintenance. Mutations or aberrant activity are linked to several neoplasms, including GISTs and clonal hypereosinophilia.
- Other names
- CD140a
02
Mechanism of action
Tyrosine kinase inhibition
03
Biological functions
Cell proliferationCell differentiationCell migrationCell survivalWound healingRegulation of cell migrationChemotaxisPlatelet activation
04
Disease associations
Gastrointestinal stromal tumors (GISTs)Clonal hypereosinophilia malignanciesCancerDevelopmental disorders
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