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Target intelligence / Profile preview
Alpha-protein kinase 1 (ALPK1)
- Target
- ALPK1
- Molecular classification
- Enzyme, Protein Kinase, Serine/Threonine Kinase, Alpha-type kinase
01
Overview
Alpha-protein kinase 1 (ALPK1) is a serine/threonine protein kinase that plays a critical role in innate immunity by detecting bacterial pathogen-associated molecular pattern metabolites (PAMPs), particularly ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), and initiating downstream inflammatory signaling pathways. It is also involved in vesicular trafficking, protein sorting, and has been implicated in several diseases including cancer, gout, chronic kidney disease, myocardial infarction, and type 2 diabetes mellitus.
02
Mechanism of action
ALPK1 phosphorylates TIFA, activating the NF-kappa-B pathway.
03
Biological functions
Innate ImmunitySignal TransductionProtein PhosphorylationVesicular TraffickingProtein SortingNF-kappa-B pathway activation
04
Disease associations
CancerGoutChronic Kidney DiseaseMyocardial InfarctionType II Diabetes MellitusROSAH syndromeInflammationBacterial Infection
05
Safety considerations
Oncogenic potential under certain conditions due to effects on cytokine secretion.
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