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Alpha-sarcoglycan (SGCA)
- Target
- SGCA
- Molecular classification
- Transmembrane protein, Sarcoglycan alpha/epsilon family
01
Overview
Alpha-sarcoglycan is a transmembrane protein encoded by the SGCA gene in humans. It is a critical component of the sarcoglycan complex, which forms part of the dystrophin-glycoprotein complex (DGC) in muscle cell membranes. The DGC links the intracellular actin cytoskeleton to the extracellular matrix, maintaining muscle fiber integrity. Mutations in SGCA cause limb-girdle muscular dystrophy type 2D (LGMDR3), characterized by progressive muscle weakness.
- Other names
- ADLDAG2Alpha-SG50 kDa dystrophin-associated glycoproteinAdhalinDystroglycan-250DAG
02
Biological functions
Stabilizes muscle fiber membranesLinks cytoskeleton & ECMStabilizes α-dystroglycan at the plasma membraneMaintains muscle fiber integrity
03
Disease associations
Limb-girdle muscular dystrophy type 2D/LGMDR3Myopathies
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