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Alpha-Secretase

Molecular classification: Enzyme, Metalloproteinase, ADAM family

Overview

Alpha-secretases are a family of proteolytic enzymes, primarily ADAM10, that cleave amyloid precursor protein (APP) within its transmembrane region. This cleavage occurs within the sequence that would otherwise generate amyloid beta (Aβ) peptide. By cleaving APP at this site, alpha-secretase precludes Aβ formation and thus participates in the non-amyloidogenic pathway of APP processing, making it a therapeutic target for Alzheimer's disease.

Other names: ADAM10ADAM17/TACEADAM9ADAM19

Mechanism of action

Enhancement of alpha-secretase activity promotes non-amyloidogenic processing of APP, reducing amyloid-beta production.

Biological functions

ProteolysisEctodomain sheddingAmyloid precursor protein (APP) processingPrevention of amyloid-beta formation

Disease associations

Neuroprotection against Alzheimer's disease

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