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Alpha-synuclein (α-syn)
- Target
- α-syn
- Molecular classification
- Intrinsically disordered protein
01
Overview
Alpha-synuclein is a small, highly abundant neuronal protein encoded by the SNCA gene. It plays a key role in synaptic vesicle trafficking and neurotransmitter release at presynaptic terminals. In Parkinson’s disease and related disorders, alpha-synuclein misfolds into insoluble aggregates that accumulate as Lewy bodies. Targeting pathological alpha-synuclein accumulation is an active area of therapeutic research.
- Other names
- SNCA
02
Mechanism of action
Targeting pathological alpha-synuclein accumulation
03
Biological functions
Synaptic vesicle traffickingNeurotransmitter releaseMolecular chaperone activityMaintenance of synaptic vesicle poolsRegulation of microtubule dynamics
04
Disease associations
Parkinson's diseaseDementia with Lewy bodiesMultiple System AtrophySynucleinopathiesNeurodegenerative disease
05
Safety considerations
Targeting the correct form of alpha-synuclein (e.g., misfolded aggregates)Ensuring therapeutic interventions do not disrupt normal alpha-synuclein function
06
Biomarkers
Changes in alpha-synuclein levels in cerebrospinal fluidChanges in alpha-synuclein levels in plasma
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