Alpha-tocopherol transfer protein-like (TTPAL)

Alpha-tocopherol transfer protein-like (TTPAL) is a protein encoded by the TTPAL gene. It is predicted to have transporter activity and to bind hydrophobic ligands, possibly functioning in the transport or sequestration of lipid molecules such as phosphatidylinositol bisphosphate, but its physiological role is currently unknown and uncharacterized. TTPAL is distinct from the well-characterized alpha-tocopherol transfer protein (TTPA), which is required for vitamin E homeostasis; mutations in TTPA, but not TTPAL, cause severe neuropathological disorders such as ataxia with vitamin E deficiency[3][4][1][2]. TTPAL localization is predicted to be membrane-associated, and it shares homology with other lipid binding and transfer proteins, but no disease associations or drug interactions have been described. Key points: - TTPAL is not the same as TTPA (the canonical alpha-tocopherol transfer protein)[5]. - Its molecular function and disease roles are not experimentally confirmed, and it is not a validated therapeutic target[3][4]. - The listed aliases are accurate and current[3][4].

Other names

TTPALC20orf121alpha tocopherol transfer protein likedJ179M20.3tocopherol (alpha) transfer protein-like

None identified (No drugs targeting TTPAL; mechanism unknown)