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Target intelligence / Profile preview
Alpha-toxin (Staphylococcus aureus) (Hla)
- Target
- Hla
- Molecular classification
- Toxin, Pore-forming toxin
01
Overview
Alpha-toxin, also known as alpha-hemolysin or Hla, is a major cytotoxic virulence factor secreted by Staphylococcus aureus. It forms a transmembrane beta-barrel pore in host cell membranes, leading to cell lysis and immunomodulation. It is a key target for vaccine and antibody therapies against S. aureus infections.
- Other names
- Alpha-hemolysinHla
02
Mechanism of action
Neutralization of alpha-toxin, inhibition of pore formation
03
Biological functions
CytotoxicityMembrane disruptionImmunomodulationPore formation
04
Disease associations
Staphylococcus aureus infectionsPneumoniaSepsis
05
Safety considerations
Potential for off-target effects if antibodies are not highly specificRisk of immune reactions to antibody therapies
06
Interacting drugs
Anti-alpha-toxin antibodies
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