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Alpha2C Adrenergic Receptor
- Molecular classification
- G protein-coupled receptor, Receptor, GPCR rhodopsin family
01
Overview
The Alpha2C adrenergic receptor (α2C adrenoceptor), encoded by the ADRA2C gene, is a GPCR that regulates neurotransmitter release from sympathetic nerves and central adrenergic neurons. It plays a critical role in cardiovascular function and CNS functions like mood regulation. Dysregulation is implicated in diseases such as Alzheimer's.
- Other names
- ADRA2CAlpha-2C adrenoceptorAlpha-2CARSubtype C4ADRA2L2ADRA2RL2
02
Mechanism of action
Alpha-2 adrenergic receptors mediate catecholamine-induced inhibition of adenylate cyclase via G proteins, modulating neurotransmitter release and affecting cardiovascular and CNS functions.
03
Biological functions
Signal transductionInhibition of adenylate cyclase activityRegulation of smooth muscle contraction and vasoconstrictionNegative regulation of insulin secretionPositive regulation of MAPK cascadeRegulation of neurotransmitter release
04
Disease associations
Neurodegenerative diseaseCardiovascular disease
05
Interacting drugs
(R)-3-Nitrobiphenyline
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