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Alpha3beta4 neuronal nicotinic acetylcholine receptor (None)
- Target
- None
- Molecular classification
- Ligand-gated ion channel, Receptor
01
Overview
The alpha3beta4 neuronal nicotinic acetylcholine receptor (α3β4 nAChR) is a subtype of nicotinic acetylcholine receptors highly expressed in autonomic ganglia and specific brain regions like the medial habenula and interpeduncular nucleus. It mediates fast synaptic transmission and plays a role in reward circuits and addiction-related behaviors. It is a pentamer formed from combinations of α3 and β4 subunits. The unique pharmacology of α3β4 nAChR makes it an attractive target for novel therapeutics aimed at substance use disorders, particularly nicotine addiction.
- Other names
- α3β4 nAChRganglion-type nicotinic receptor
02
Mechanism of action
Ligand binding opens the ion channel, allowing influx of Na+ and Ca2+ and efflux of K+, leading to neuronal excitation.
03
Biological functions
Signal transductionNeurotransmissionIon transportPostsynaptic excitationPresynaptic excitation
04
Disease associations
AddictionSubstance use disorders
05
Safety considerations
Potential for affecting autonomic nervous system functionsNon-selective antagonists may have broad cholinergic effects
06
Interacting drugs
Acetylcholine
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