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Target intelligence / Profile preview
Alpha3beta4 nicotinic acetylcholine receptor (α3β4 nAChR)
- Target
- α3β4 nAChR
- Molecular classification
- Ligand-gated ion channel, Nicotinic acetylcholine receptor
01
Overview
The alpha3beta4 nicotinic acetylcholine receptor (α3β4 nAChR) is a subtype of neuronal nicotinic acetylcholine receptors, playing a critical role in fast synaptic transmission within the autonomic ganglia and adrenal medulla. It is also present in specific brain regions like the medial habenula (MHb) and interpeduncular nucleus (IPN), implicated in reward circuits and addiction behaviors. Activation leads to rapid depolarization due to cation influx. It has emerged as a promising target for anti-addiction therapies.
- Other names
- Ganglion-type nicotinic receptor
02
Mechanism of action
Agonist or antagonist binding modulates ion channel opening and cation flux.
03
Biological functions
Fast synaptic transmissionNeuronal excitability modulationAutonomic functionReward processingSensory modulation
04
Disease associations
AddictionLung cancer
05
Safety considerations
Potential for off-target effects on other nicotinic receptor subtypes
06
Interacting drugs
Acetylcholine
22 more in the full profile.
07
Biomarkers
CHRNA5/A3/B4 gene cluster variations
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