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Target intelligence / Profile preview
Alpha7 Nicotinic Acetylcholine Receptor (α7 nAChR)
- Target
- α7 nAChR
- Molecular classification
- Ligand-gated ion channel, Cys-loop receptor, Receptor
01
Overview
The alpha7 nicotinic acetylcholine receptor (α7 nAChR) is a homopentameric ligand-gated ion channel highly permeable to calcium ions. It plays critical roles in the central nervous system and peripheral tissues, mediating fast synaptic transmission, regulating neurotransmitter release, and influencing cognitive processes. It is also involved in modulating inflammatory responses and angiogenesis. The α7 nAChR is a therapeutic target for several conditions, including Alzheimer's disease, schizophrenia, and inflammatory disorders.
02
Mechanism of action
Agonist-induced activation leading to increased Ca²⁺ influx and downstream signaling.
03
Biological functions
Fast synaptic transmissionNeurotransmitter release regulationCell excitability regulationNeuronal integrationMemory formation/retentionLearning abilityWorking memory maintenanceAttention spanModulation of inflammatory responsesAngiogenesis regulationApoptosis/survival signaling
04
Disease associations
Alzheimer's diseaseStrokeMyocardial infarctionSepsisSchizophreniaSmoking addictionAtherosclerosisCancer
05
Safety considerations
Potential proatherogenic actions depending on cell type/contextual factorsComplex effects on immune modulation, requiring careful consideration in inflammatory conditions
06
Interacting drugs
Acetylcholine
4 more in the full profile.
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