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Target intelligence / Profile preview
Altered Antigen Presentation (AAP)
- Target
- AAP
- Molecular classification
- Cellular Process, Immune Process
01
Overview
Altered antigen presentation refers to changes in how antigens are processed and displayed to T cells, impacting T cell activation, function, and fate. It involves modifications in antigen processing, MHC molecule expression, co-stimulatory molecule presentation, and the kinetics of peptide-MHC display. These alterations can lead to various outcomes, including T cell anergy, immune escape, or enhanced immune responses, depending on the context. Altered antigen presentation plays a crucial role in diseases such as cancer and autoimmunity and is a target for immunotherapeutic interventions.
- Other names
- Suboptimal Antigen PresentationAberrant Antigen PresentationDefective Antigen Presentation
02
Mechanism of action
Varies depending on the specific alteration and therapeutic intervention. Can involve enhancing antigen presentation, blocking inhibitory signals, or inducing tolerance.
03
Biological functions
T cell activationImmune toleranceImmune evasionAntigen processing and presentation
04
Disease associations
CancerAutoimmunityInfectionImmunodeficiency
05
Safety considerations
Off-target effects on immune responsesInduction of autoimmunityImmune suppressionCytokine release syndrome
06
Interacting drugs
Immunosuppressants
3 more in the full profile.
07
Biomarkers
MHC expression levelsCo-stimulatory molecule expressionT cell activation markersCytokine profiles
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