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Alternative Complement Pathway (ACP)

Target: ACP
Molecular classification: Enzyme Cascade, Immune Pathway

Overview

The alternative complement pathway is one of the three main pathways of the complement system, a crucial component of innate immunity. Unlike the classical and lectin pathways, it does not require antibodies or specific recognition molecules to initiate activation. Instead, it is triggered by spontaneous hydrolysis ("tickover") of complement protein C3 or by direct binding of C3b to pathogen surfaces or foreign materials.

Mechanism of action

Modulation of complement activation

Biological functions

OpsonizationDirect KillingInflammationClearanceImmune Response

Disease associations

Atypical hemolytic uremic syndromeAge-related macular degenerationIschemic injuryInflammatory diseasesAutoimmunityInfection

Safety considerations

Uncontrolled activation leading to host tissue injuryIncreased susceptibility to infections or autoimmune/inflammatory diseases due to dysregulation

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