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Target intelligence / Profile preview
M2 Macrophage (M2)
- Target
- M2
- Molecular classification
- Immune cell, Myeloid cell
01
Overview
M2 macrophages are a subset of macrophages characterized by their anti-inflammatory, tissue repair, and immunoregulatory functions. They promote ECM production, angiogenesis, and clearance of apoptotic cells, and secrete anti-inflammatory cytokines such as IL-10 and TGF-β. They are involved in wound healing, tissue remodeling, resolution of inflammation, and immune regulation. While generally considered beneficial, dysregulated activity can contribute to pathological conditions.
- Other names
- Alternatively activated macrophage
02
Mechanism of action
N/A
03
Biological functions
Anti-inflammationTissue repairWound healingImmunoregulationAngiogenesisPhagocytosis
04
Disease associations
Wound healingResolution of inflammationAllergic inflammationTumor progressionMetastasisChronic infection reservoirsAtherosclerosis
05
Safety considerations
Excessive or dysregulated activity can contribute to allergic inflammation, tumor progression/metastasis, and chronic infection reservoirs
06
Interacting drugs
Glucocorticoids
5 more in the full profile.
07
Biomarkers
Arginase 1 (Arg1)Mannose receptor CD206Chitinase-like protein Ym1Fizz1CCL17CCL18CCL22MerTKCCL16
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