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Target intelligence / Profile preview
Amb a 1 Protein (Amb a 1)
- Target
- Amb a 1
- Molecular classification
- Enzyme, Pectate Lyase
01
Overview
Amb a 1 is the major allergen found in the pollen of short ragweed (*Ambrosia artemisiifolia*). It is a pectate lyase enzyme and a primary cause of ragweed pollen allergy, responsible for over 90% of IgE-mediated responses in sensitized individuals. It is a key marker for diagnosing ragweed pollen sensitization and a target for allergen-specific immunotherapy.
- Other names
- Antigen EShort Ragweed Allergen
02
Mechanism of action
Target of allergen-specific immunotherapy (e.g., allergy shots) aims to desensitize the immune system to Amb a 1.
03
Biological functions
Pectate lyase activityCell wall modificationPollen tube growthAllergen
04
Disease associations
Allergic rhinitisRhinoconjunctivitisAsthmaRagweed pollen allergy
05
Safety considerations
Potential for allergic reactions during immunotherapy
06
Biomarkers
Specific IgE against Amb a 1
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