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Target intelligence / Profile preview
Ragweed Allergen
- Molecular classification
- Protein, Allergen
01
Overview
Ragweed allergen refers to the proteins found in ragweed pollen that trigger allergic reactions in sensitized individuals. The major allergens are designated Amb a allergens, with Amb a 1 and Amb a 11 being among the most studied. Exposure leads to symptoms such as sneezing, runny nose, itchy eyes, and can exacerbate asthma. Diagnosis is typically performed via skin prick tests or specific IgE assays. Immunotherapy is a desensitization treatment aimed at reducing symptom severity.
- Other names
- Ambrosia allergenAmb a 1Amb a 11Ragweed pollen allergen
02
Mechanism of action
Ragweed allergens bind IgE antibodies on mast cells/basophils, triggering release of histamine and other mediators, leading to hypersensitivity reactions.
03
Biological functions
Pollen development (in plants)Defense (in plants)IgE-mediated immune response (in humans)Allergen
04
Disease associations
Allergic rhinitisAsthmaAllergic conjunctivitisOral Allergy SyndromeRagweed rash
05
Safety considerations
Anaphylaxis (rare, but possible with immunotherapy)Side effects of medications (e.g., drowsiness with antihistamines, immunosuppression with corticosteroids)
06
Interacting drugs
Antihistamines
3 more in the full profile.
07
Biomarkers
Specific IgE levels to ragweed pollenSkin prick test reactivity to ragweed pollen
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