Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Amido Phosphoribosyltransferase (ATase)
- Target
- ATase
- Molecular classification
- Enzyme, Phosphoribosyltransferase, Ntn hydrolase family
01
Overview
Amido Phosphoribosyltransferase (ATase), also known as Glutamine phosphoribosylpyrophosphate amidotransferase (GPAT), is an enzyme that catalyzes the first committed step in de novo purine nucleotide biosynthesis. It converts 5-phosphoribosyl-1-pyrophosphate (PRPP) and glutamine into 5-phosphoribosylamine (PRA), glutamate, and pyrophosphate (PPi). The enzyme is composed of two functional domains: a glutaminase domain that hydrolyzes glutamine to produce ammonia, and a phosphoribosyltransferase domain that transfers ammonia to PRPP. ATase is subject to feedback inhibition by downstream products such as AMP and is a target for antifolate drugs used in cancer chemotherapy.
- Other names
- AmidophosphoribosyltransferaseGlutamine phosphoribosylpyrophosphate amidotransferaseGPAT
02
Mechanism of action
Inhibition of purine synthesis by blocking the first committed step, leading to decreased DNA/RNA production and cell proliferation.
03
Biological functions
De novo purine nucleotide biosynthesisPurine synthesis
04
Disease associations
CancerCell proliferation disorders
05
Safety considerations
Potential for toxicity due to disruption of nucleotide synthesis in normal cells.Development of drug resistance.
06
Interacting drugs
Antifolates (e.g., Piritrexim)
1 more in the full profile.
Beyond the preview
Go deeper on Amido Phosphoribosyltransferase (ATase).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Amido Phosphoribosyltransferase (ATase).