Amidohydrolase domain-containing protein 1 (AMDHD1)

Amidohydrolase domain-containing protein 1 (AMDHD1) is a cytosolic enzyme central to histidine catabolism, specifically catalyzing the conversion of 4-imidazolone-5-propionic acid to formiminoglutamic acid. It is highly expressed in the liver and is selectively induced during intestinal stem cell formation, particularly in response to thyroid hormone during amphibian metamorphosis. The protein is evolutionarily conserved and linked to metabolic and developmental processes, vitamin D homeostasis, and cancer biology. Functional studies indicate AMDHD1 acts as a tumor suppressor by enhancing SMAD4 stability and regulating the cell cycle through the p21/CDK4 pathway, and altered expression can serve as a disease biomarker in multiple cancers. There are currently no known direct drug interactions or documented safety concerns associated with therapeutic targeting of AMDHD1.

Other names

Probable imidazolonepropionaseHMFT1272MGC35366Amidohydrolase domain-containing protein 1HUTI_HUMAN (protein form)

not applicable / null (no drugs targeting AMDHD1 have been described; the protein’s physiological mechanisms involve enzymatic conversion of intermediates in histidine metabolism, and tumor suppression via stabilization of SMAD4)