Target intelligence / Profile preview

Amidohydrolases

Molecular classification: Enzyme, Hydrolase

Overview

Amidohydrolases are a diverse class of enzymes that catalyze the hydrolysis of amide bonds in both linear and cyclic amides. They play key roles in metabolic pathways and are involved in processes like pyrimidine and purine catabolism, and nitrogen metabolism. Some amidohydrolases are being explored in cancer therapy through Gene Directed Enzyme-Prodrug Therapy (GDEPT), where they activate prodrugs like capecitabine within tumor cells. Certain solvent-tolerant amidohydrolases also have potential applications in pharmaceutical manufacturing and biocatalysis.

Mechanism of action

Hydrolysis of amide bonds, Prodrug activation

Biological functions

Hydrolysis of amide bondsPurine degradationPyrimidine catabolismNitrogen metabolism

Disease associations

Cancer

Safety considerations

Off-target effects in Gene Directed Enzyme-Prodrug Therapy (GDEPT)Potential for toxicity from active metabolites

Interacting drugs

Capecitabine

Beyond the preview

Go deeper on Amidohydrolases.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Amidohydrolases.

Explore the full profile