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Target intelligence / Profile preview
Epithelial Sodium Channel Alpha Subunit (ENaC α)
- Target
- ENaC α
- Molecular classification
- Ion channel, ENaC/DEG superfamily
01
Overview
The epithelial sodium channel (ENaC) is a membrane-bound, non-voltage-gated ion channel that is highly selective for sodium ions (Na+). The alpha subunit of ENaC is encoded by the *SCNN1A* gene and is considered essential for forming an active channel at the cell surface. It plays a critical role in the regulation of sodium and water homeostasis across epithelial tissues, particularly in the kidney, lung, colon, and sweat glands. Dysfunction or mutations affecting ENaC α can lead to disorders such as Liddle syndrome, cystic fibrosis, and pseudohypoaldosteronism type I.
- Other names
- SCNN1AAmiloride-sensitive sodium channel subunit alphaAlpha-NaCHNonvoltage-gated sodium channel 1 subunit alphaSCNEAAlpha-ENaC
02
Mechanism of action
Blocks ENaC activity by targeting the pore region formed by transmembrane domains.
03
Biological functions
Sodium reabsorptionRegulation of airway surface liquidSalt taste perceptionElectrolyte balance
04
Disease associations
HypertensionCystic fibrosisPseudohypoaldosteronism type IPulmonary edemaCOPD
05
Safety considerations
Electrolyte imbalance
06
Interacting drugs
Amiloride
1 more in the full profile.
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