Aminergic G protein-coupled receptor (None (GPCR is the accepted family abbreviation, but not for a specific receptor))

Aminergic G protein-coupled receptors are a group of class A GPCRs that bind endogenous biogenic amines—such as dopamine, serotonin, histamine, norepinephrine, epinephrine, and acetylcholine (muscarinic)—as neurotransmitters or hormones. Subfamilies include adrenergic, dopaminergic, serotonergic, histaminergic, muscarinic, and trace amine receptors. These receptors possess seven transmembrane domains and function primarily by activating intracellular G proteins and other signaling cascades upon ligand binding. Due to their central roles in neurotransmission and their tissue-specific expression, aminergic GPCRs are major drug targets for central nervous system, cardiovascular, metabolic, and other disorders. However, the term "multiple aminergic GPCRs" denotes a pharmacologically and structurally diverse group, not a single defined target, hence it is not appropriate for precise molecular or therapeutic annotation.

Other names

aminergic GPCRbiogenic amine GPCRaminergic receptor

Agonism (direct receptor activation), Antagonism (receptor blockade), Partial agonism, Inverse agonism, Modulation of downstream signaling (biased agonism, allosteric modulation)